Top Ten Things Not to Do at the First Singing of Silent Night in 1818

Photo by Thomas Galler on Unsplash

This post ran on December 24th, 2018. I hope you can enjoy it again.

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This Top Ten list of what not to do continues with a historical backdrop. On December 24th, 1818, the Christmas carol “Silent Night” composed by Franz Xaver Gruber was first sung at St Nicholas parish church in Oberndorf, Austria. If you time travel, here is a list that might keep you from making a mistake and prepare you for a Merry Christmas.

Top Ten Things Not to Do at the First Singing of Silent Night in 1818 by John W. Howell © 2018

10 If you are at the first singing of Silent Night, do not sing off-key. If you do, at best, the crowd will cover you up. At worst, the choir director will call a couple of big guys and have you removed. (We know you love to sing, Gerrald. You just have to sing more quietly.)

9 If you are at the first singing of Silent Night, do not try to avoid contributing to the collection plate being passed by Tiny, the WWF champ. If you do, at best, Tiny won’t notice. At worst, Tiny, who promised 10% of his earnings to the church, will take offense. (Being held upside down and shaken until the coins fall is not the best thing, Gerritt. It sure beats a windmill body slam, though.)

8 If you are at the first singing of Silent Night, do not wear your “Happy Birthday JC” Christmas sweater. If you do, at best, most will not understand the message. At worst, a six-foot-seven Knight of the Templer will take it upon himself to eliminate your sweater ( I think I would offer to take the garment off and do some kind of penance, Giacomo. Otherwise, he will keep applying pressure to your head.)

7 If you are at the first singing of Silent Night, do not arrive late for the service. If you do, at best, there will be a seat in the back pew. At worst, you will be directed to the front bench. (While you are taking that long walk, Gibson, the director, is holding his baton in mid-air, waiting for you to reach your seat. Good thing you wore a red scarf. Your face matches it correctly.)

6 If you are at the first singing of Silent Night, do not think you know the words, and avoid using the hymnal. If you do, at best, you’ll only be noticed by a few. At worst, the entire congregation will be nudging each other and pointing, as you get most wrong. ( You can almost feel the mocking, can’t you, Gille? Wait until you turn around to leave.)

5 If you are at the first singing of Silent Night, do not fall asleep during the sermon. If you do, at best, only the priest will know. At worst, your snoring is the subject of more than a few giggles. (Sadly, the priest decides to use you as an example of the sinning world. Oh, and don’t compliment the priest on his sermon on the way out, Gimle.)

4 If you are at the first singing of Silent Night, do not finish that 32-ounce big gulp tankard before you arrive at the service. If you do, at best, the service will be short. At worst, the service turns into the highest mass with the most ritual possible. (After the first hour, you are beginning to openly sweat, Girisha. I would pray harder for mercy.)

3 If you are at the first singing of Silent Night, do not wear your Long Live France t-shirt. If you do, at best, most will not remember the War of the Seventh Coalition in 1815. At worst, most of the congregation are veterans of the war. (It looks like you have hit a sore point, Guiliano. I think you might want to exit through the side door.)

2 If you are at the first singing of Silent Night, do not go a-wassailing for too many wassails before the service. If you do, at best, the cold night air will straighten you out. At worst, you’ll accidentally do a header into the pew in front of you. (I know you just meant to bow your head, Gleipnif. Try telling that to the spinster on whom you are laying.)

1 If you are at the first singing of Silent Night, do not try to sneak out without shaking the priest’s hand. If you do, at best, the side door will be unlocked. At worse, you choose the wrong door and realize you are now in the priest’s vestment room. (Funny how that door locked behind you, Godfrey. You will now have the pleasure of explaining precisely what you are doing here once the priest is finished shaking hands.)

Views of the Neighborhood – Decorations

Today, we will cruise the neighborhood and highlight some of the decorations. We are catered by Bufalina of Austin, and our entertainment is Carpool Karaoke.

Menu

pizza

marinara – tomato, garlic, oregano

margherita – tomato, mozzarella, basil, parm

red pie – tomato, double garlic, double parm, chili flake, oregano pepperoni

calabrese – tomato, salami, mozzarella, serrano, garlic, basil

taleggio – mozzarella, sausage, scallion

chinese broccoli – mozz, sausage, parm cream, calabrian chilis, garlic

fresca – mozzarella, prosciutto, arugula, lemon, parm

‘nduja – mozzarella, spiced pork sausage, artichoke, onion, parm

squash – mozzarella, chimichurri, pecorino, sesame seed

mushroom – mozzarella, caramelized onion, parm cream, piparra

anchovy – tomato, mozzarella, fennel, capers, basil, chili flake

Picture of an old time school bus

Hop on the bus

Casual reindeer.

Our old friend, the armadillo

Mr. Happy Turtle.

Giant reindeer.

Scrooge’s decoration.

The Halloween house is decorated for the holidays.

A night view of the Halloween house.

A long view of the most extensive display.

A little closer shot of Santa and Rudolf, the red-nosed longhorn.

Another Santa.

Lovely scene

Peace on Earth.

That is the tour, so it is time to relax with food and entertainment. I hope you have a great week.

Stream of Consciousness Saturday – Prompt – “Bake”

A picture of a string with drops of water- the logo for SoCS

With a cup of coffee, one can conquer the world. Or so it would seem. My machine is being very kind to me and producing the best of the best. After half a cup, the alarm comes to mind. Taking one last safty excursion to December 16, 1923. Notwithstanding all the advice last week from my dear friend the safe road is it. I certainly don’t want to bake my time travel cake half way.

The clock is set to December 16th 1923 ,7:00 PM, and the duration is set to two hours. The scene is a darkened theater and the movie Our Hospitality is playing. It stars Buster Keaton and is one of the most popular. The audience loves it  and can’t seem to get enough. Also appearong is the movie is Natalie Talmadge, Joe Keaton, and Joe Roberts. It is very strange to be in a movie with people smoking. The screen gets harder to see as the movie finishes.

Moving to the lobby there is a  poster for the movie playing next.

Slow as Lighting is playing next. It stars Kenneth MacDonald, Billy ‘Red’ Jones, Edna Pennington, Gordon Sackville. Not a title that is familar to me.

The alarm goes off and I land back on the couch. I receive a text from Linda Hill. It says Your Friday prompt for Stream of Consciousness Saturday is: “bake.” Use it as a noun or a verb, use it any way you’d like. Have fun!

If you want to see what other bloggers do with the prompt visit Linda’s post. Here is the link. https://lindaghill.com/2023/12/15/the-friday-reminder-and-prompt-for-socs-dec-16-2023/

Bake by John W. Howell © 2023.

“Well I see your 100 year deal continues.”

“Yeah well I sure don’t want to make a mistake.”

“Okay I get that. Do you want me to go with you on the next?”

“Nice of you to offer but that isn’t necessary.”

“Why not. I would love to bake time travel into my experience cake.”

” think we would be falling over each other and then there’s the issue of the time continuum.”

“What’s that.”

“Something that we can’t disturb.”

“Like I would.”

“I’m just saying that anyone who would order a leaf vaccum for an Uber ride is capable of tearing the time continuum.”

“I thought it was aneat ride.”

“See. My point exactly.”

“This diascussion leads me to want a VooDoo Ranger.”

“Can’t wait to see wht you ordered from Uber.”

“It has plenty of room.”

“So does a cattle car. Can’t wait to see what you have.”

“There it is.”

Photo by Dan Antion

“OMG.”

“It’s all decked out for the holidays.”

“Who are those people on there?”

“Carolers. They are going to sing some carols.”

“Is there hay on the wagon to keep us warm and hot chocolate.”

“No on both. We are after VooDoo Rangers not flavored lactose.”

“Well, still woud have been nice.”

“Come on. You a Ranger or a wimp?”

“Just glad I brought a coat we are not exactly going to bake in the sun in that thing.”

“I hope you are happy to get that prompt off your chest.”

“Very. Lets go.”

 

 

 

Friday JohnKu – AKA -TGIF – Fri-Yay/Good News

Today’s story is from the Associated Press.

A sea otter pup found alone in Alaska has a new home at Chicago’s Shedd Aquarium.

CHICAGO (AP) — An 8-week-old arrival from Alaska chirps loudly before devouring ice chips in the nursery at Chicago’s Shedd Aquarium.

He is Pup EL2306 — proper name to be determined — a northern sea otter who was found alone and malnourished in the remote town of Seldovia in October and taken to the Alaska SeaLife Center in Seward.

Shedd, one of only a few facilities in the United States with the resources to care for rescued otters, was contacted by the SeaLife Center, and the aquarium’s otter team made the cross-country journey with the fluffy brown marine mammal who arrived in Chicago at the end of November.

“Caring for a little otter pup is just like caring for an infant,” including round-the-clock feeding, said Lana Gonzalez, a manager of penguins and otters at Shedd. “He also needs to get groomed. Sea otters have a very dense coat — there’s anywhere from 700,000 to a million hairs per square inch, and that’s what they use to keep themselves warm. They don’t have a thick layer of blubber or fat like other marine mammals do, so taking care of that coat is very important.

An otter mother would typically teach her offspring to groom. The aquarium team acts in her place to encourage the pup’s healthy development.

On Wednesday, otter supervisor Tracy Deakins entered the pup’s enclosure with clean white towels and encouraged him to leave the water. Deakins pointed to different spots on his fur, and the pup responded by licking or rubbing it with his paws.
An eight-week-old sea otter rescued from Seldovia, Alaska, chews on ice chips in his enclosure at Shedd Aquarium Wednesday, Dec. 6, 2023, in Chicago. (AP Photo/Erin Hooley)

An eight-week-old sea otter rescued from Seldovia, Alaska, chews on ice chips in his enclosure at Shedd Aquarium Wednesday, Dec. 6,

The pup will remain in Shedd’s Regenstein Sea Otter Nursery for a few months, building bonds with the staff, and he will eventually be introduced to the otter habitat and the five other otters at the aquarium.2023, in Chicago. (AP Photo/Erin Hooley)

 

Part of the growth process is moving pups from formula and small bits of clam to other solid foods. Gonzalez mentions the clam is “restaurant quality” and sustainably sourced.

Rescued pups are usually designated by the federal government as non-releasable, and the Shedd experts said pups need their mothers for the first year of life.

Tracy Deakins grooms an eight-week-old sea otter rescued from Seldovia, Alaska, in his enclosure at Shedd Aquarium Wednesday, Dec. 6, 2023, in Chicago. The otter was found alone and malnourished and was taken to the Alaska SeaLife Center in Seward, Alaska, which contacted Shedd, and the Chicago aquarium was able to take the otter in. He will remain quarantined for a few months while he learns to groom and eat solid foods before being introduced to Shedd's five other sea otters. (AP Photo/Erin Hooley)

Tracy Deakins grooms an eight-week-old sea otter rescued from Seldovia, Alaska, in his enclosure at Shedd Aquarium Wednesday, Dec. 6, 2023, in Chicago. (AP Photo/Erin Hooley)
Tracy Deakins grooms an eight-week-old sea otter rescued from Seldovia, Alaska, in his enclosure at Shedd Aquarium Wednesday, Dec. 6, 2023, in Chicago. The otter was found alone and malnourished and was taken to the Alaska SeaLife Center in Seward, Alaska, which contacted Shedd, and the Chicago aquarium was able to take the otter in. He will remain quarantined for a few months while he learns to groom and eat solid foods before being introduced to Shedd's five other sea otters. (AP Photo/Erin Hooley)

Tracy Deakins grooms an eight-week-old sea otter rescued from Seldovia, Alaska, in his enclosure at Shedd Aquarium Wednesday, Dec. 6, 2023, in Chicago. (AP Photo/Erin Hooley)

“Once we bring him into our care, he won’t be released back out into the natural environment, they’re just too used to people. But the good news is that he’ll be able to be an ambassador for his species here at the aquarium, so we’re really happy about that,” said Gonzalez.

The good news here is that a life was saved, and there are people who care about wildlife welfare. Today’s JohnKu talks about wildlife rescue. I hope you have a great weekend.

Life by John W. Howell © 2023

What is the measure?

Placed on a life worth saving . . .

Only human count?

Thursday – A Little Personal – Twiggy and Her Leash

“I’m just going into the backyard. Why the leash?

“We need to protect your leg in case you have a wild moment.”

“A wild moment? Haven’t had one of those in weeks.”

“Yes, and we must keep it like that until the end of January.”

“I don’t know, but visiting the backyard with a chaperone is not the same.”

“It won’t be forever. Just think how far you’ve come.”

“Yeah, well, at least I’m walking better. Those leaves back there need some attention.”

“You are walking better. I know about the leaves. They will be done tomorrow.

“Maybe we can take a quick sunbath. The sun is warm.”

“That’s the spirit. You want to lay on the lounges?”

“Um, no. The sun isn’t that warm. We need a geophysical boost.”

“A geophysical boost? What’s that?”

“Black rocks and exposed groundcover where Mom pulled a plant.”

“Oh, I get it. The rock absorbs the heat, and so it’s warmer there.”

“I have to wonder sometimes what they taught you in college.”

“I may have missed the class where they covered how to get warmer outside.”

“I think you guys have lost some of the skills necessary to survive out here. Too many comforts.”

“Says the dog who never wants for a thing.”

“Yeah, but I still keep my instincts sharp.”

“Like chasing things til you blow out a ligament?”

“Okay, there’s that. Let’s go in. It’s a little chilly.

Tuesday – Anything Possible – Kreative Kue #411 by Keith Channing

In Keith’s words. “Using this photo (below) as inspiration, write a short story, flash fiction, scene, poem; anything, really; even just a caption for the photograph. Either put your offering (or a link to it) in a comment or email it to me at keithchanning@gmail.com before Sunday evening UK time. If you post it on your own blog or site, a link to this page would be appreciated, but please do also mention it in a comment here. Thank you for taking part.”

Keith’s post. https://keithchanning.wordpress.com/2023/12/11/kreative-kue-411/

The Photo.

Slow News Day by John W. Howell © 2023

“And now our reporter Max Fly in the Far East has a story about an obscure music maker.”

“That’s right, Bradley. I am here in Thailand with what has been reported as the only miniature bed of nail player in the world. Let me introduce you to Chakan Chokdee. Hello, Chakan.”

“Hello Mr, Fly.”

“You can call me Max.”

“Ah. Hello, Max.”

“Your English is perfect. Where did you learn it?”

“Stanford University. PhD in biostudies.”

“So, tell our audience about your instrument.”

“Yes. This is a miniature bed of nails, and instead of taking a nap on it, I play it.”

“And how do you do that?”

“Well, you hold it like this and pluck each nail.”

“Can you play it for us?”

“Sure, what would you like to hear?”

“For this demonstration, how about something traditional.”

“Ah, let me see. Yes, here is a traditional song.

Pluck – You say you are lookin’ for trouble?

Pluck – Well, son, you’ve come to the right place.

Pluck – Notice that I have this fist of iron.

Pluck – That’s got a reserved sign for your face.”

“Now that is an interesting folk song. What’s its name?”

“It is an ancient song that tells a story of cultural conflict.”

“I can imagine. What’s it called?”

“Mæ̀ k̄hxng khuṇ s̄wm rxngthêā būth t̀xs̄ū̂“

“Hmm. I wonder if you could translate that for our worldwide audience.”

“I’m not sure it would mean the same in English.”

“Give it a try.”

” Okay. The exact translation is Your Mother Wears Combat Boots.”

“I think we can understand that just fine. Back to you in the studio, Bradley.”

Top Ten Things Not to Do at a Holiday Party

Photo by Artem Kniaz on Unsplash

This post was initially run on December 16th, 2016. Parties and our behavior at them have not changed much, so I hope you enjoy it again. If you remember it from the last time, you probably don’t need the advice given here.

* * *

The inspiration for this list has been an adult life-long fascination with human interactions. There is no time like the holidays to go out and get an actual feeling of how people interrelate. I may have published some of these points under a different context, but it still bears repeating some of the advice again. I cannot swear I haven’t done any of these, but I don’t think so. Also, a message to the Yale School of Psychology. This is all in fun and should not be used as part of the curriculum dealing with Holiday stress. With that disclaimer, here we go.

The Top Ten Things Not to Do at a Holiday Party

10 At a holiday party, do not assume because the drinks are free, you can have all you want. If you do, at best, you will find the next morning that the drinks were not free after all. At worst, you might wake up in the guest room bathtub and have no idea how you got there. (Your host was very pleased when you locked the door to the only bathroom in the house. Too bad the pounding on the door didn’t give you a hint, Bunky.)

9 At a holiday party, do not think an informal atmosphere will lend itself to getting closer to your boss. If you do, At best, you will only say one stupid thing. At worst, you wake up at 3:00 am realizing you told your boss exactly what you thought of the latest project. (Now you also remember the hurt look on the boss’ face since it was a pet project. Maybe you can say you had a brain aneurysm, huh, Ferd?)

8 At a holiday party, do not double dip from the crab spread. If you do, at best, no one will notice, and you’ll be safe. At worst, unfortunately, you chose the moment when the boss was doing a video panorama and are now a piece of history. (The playback at the office caused a noticeable groan from your co-workers, and several grabbed their zinc inhalers. Why you had to sneeze right after the double dip is anybody’s guess.)

7 At a holiday party, do not think of arriving without a host gift. If you do, at best, you might be able to sneak in unnoticed. At worst, the host had requested in the invitation to bring an unwrapped toy for a needy child. (That will teach you to ignore letters. You never sent an RSVP either, did you, Buster?)

6 At a holiday party, do not think everyone wants to sing carols. If you do, at best, you may be doing a solo. At worst, you will be so annoying that the host will ask his cousin Tiny, with WWF champ, to see you to the door. (Tiny’s method of seeing people to the door is very similar to his winning body slam in the ring. Don’t worry, nothing’s broken. It’s all fake, remember?)

5 At a holiday party, do not try to get away with bringing a  cheap bottle of wine as a gift. If you do, at best, no one will see you set it down. At worst, your host will thank you and suggest that you open it immediately to share with the guests. (Two-buck Chuck is so well-known, Oscar, that your face is now the color of the wine.)

4 At a holiday party, do not attempt to have controversial discussions with each conversation. If you do, at best, you’ll end up talking to the dog. At worst, you’ll spark a debate that will ultimately engulf the entire room and eventually lead to the arrival of a SWAT team. (Well, you did learn that politics is a hot subject, didn’t you, Bucky?)

3 At a holiday party, do not think you have to entertain everyone with your jokes. If you do, at best, you’ll find out quickly you are no Henny Youngman. At worst, most in attendance will enquire of the host about that strange person who is not funny. (The beautiful thing is your boss’ boss took down your name which should lead to some good stuff. Maybe at the next company, huh, Milton?)

2 At a holiday party, do not suggest everyone go out into the snow to see how beautiful the lights look. If you do, at best, no one will follow you. At worst, your host will open the front door and promptly slam and lock it after you are gone. (It seemed like a good idea at the time, didn’t it, Roscoe?. Now you need to call and get your shoes back.)

1 At a holiday party, do not ignore someone who asks for your keys. If you do, at best, you will be breaking the law. At worst, you could be responsible for hurting yourself and, more importantly, an innocent victim. (Obviously, we all should remember not to drink and drive this holiday season.)

Views of the Neighborhood – Lakeway Trail of Lights

We are going to visit the Trail of Lights in Lakeway. This annual tradition is under the auspices of the Lakeway Parks and Recreation. We are catered by Interstellar BBQ of Austin. Our entertainment is Martina Mc Bride and Elvis.

Menu

BEEF KIELBASA
All beef traditional Polish-style sausage in a pork casing
JALAPEÑO POPPER SAUSAGE
Beef and pork blend in a pork casing, jalapenos, and chunks of gooey cheddar
CHOPPED BRISKET
Chopped ends sauced with Johnny’s Texas Red Sauce
PEACH TEA GLAZED PORK BELLY
Slowly smoked until tender, then glazed with our homemade peach tea glaze
TURKEY
Turkey breast brined in citrus, herbs, and Live Oak Hefeweizen, seasoned with salt and pepper.
PORK SPARE RIBS
Duroc pork spare rib; a little sweet, a little spicy
PULLED LAMB SHOULDER
Juicy pulled lamb shoulder seasoned with salt, pepper, garlic, and a splash of rice vinegar
BRISKET
USDA prime all-natural brisket seasoned with salt, pepper & garlic
Picture of an old time school bus
Let’s get on the bus.
We’ll just follow the signs.
Santa’s elf welcomes us.
Tree, Santa, and all the reindeer.
A campout scene.
The toy train.
The North Pole.
A far-away shot with the trail.
Mushrooms, birds, and flowers.
Ice skaters.
Stagecoach.
Several animals and a butterfly.
A last look back at a trail. I couldn’t hope to publish all the lights, but you know how festive this display is. Time now to relax, eat, and listen to the music. I hope you have a super week.

Stream of Consciousness Saturday – Prompt “To Me”

A picture of a string with drops of water- the logo for SoCS

The coffee is ready in record time, which just says to me, “We love you, boss.” After a sip of the precious fluid, the thought again turns to the alarm clock. Although experience is being gained on each trip to maintain control, it seems to me that staying within a specific boundary is a good idea.

Therefore, the clock is set to December 8th, 1923. One hundred years ago. The time is set for two hours, and the plunger is pulled. Immediately, the scene changes, and My location is Madison Square Garden. There are a lot of people in the garden cheering for men on bicycles.

When questioned, the guy next to me informs me that this is the finish of the annual December Six-day race. He tells me there are fourteen thousand people in attendance.

He also says Ernest Kockler of Chicago and Percy Lawrence of San Francisco, comprising the American team, were the winners of the annual race. He fascinated me with what seemed to me to be a professional play-by-play recap of the events. He breathlessly recapped that the American riders, hanging tenaciously to the precious lap that they gained during one of the jams early in the week, finished the grind with a total mileage of 2,519 miles and 8 laps, and their one-lap margin was sufficient to give them the honors.

Thanking him for the information, the bell clanging means my time is up here in New York. In an instant, the familiar surroundings of the home told me the adventure is over. My phone buzzes, and a text arrives from Linda Hill. It reads.

Your Friday prompt for Stream of Consciousness Saturday is: “to me.” Find a way to use the phrase “to me” in your post. Use it any way you’d like. Enjoy! To see what other bloggers have done with this prompt, visit Linda’s post. Here is the link: https://lindaghill.com/2023/12/08/the-friday-reminder-and-prompt-for-socs-dec-9-2023/

To Me by John W. Howell © 2023

“To me, this alarm thing needs to be ramped up.”

“What do you mean.”

“You’re stuck in going back 100 years.”

“Yeah, like I explained so as not to run into trouble.”

“Come on. There are more interesting things to see other than a bunch of sweaty jocks on bikes.”

“I suppose you are right.”

“Darned right, I’m right.”

“I  guess we could look up an event we wanted to visit.”

“Yeah, Like the ending of prohibition or Crusades. Anything but the 1920s.”

“Okay, next week we’ll try it.”

“Great. Let’s go celebrate.”

“Unlike every week.”

“Oh, come on. You know what I mean.”

“Did you order Uber?”

“He’s right over there.”

“I don’t see him.”

“That orange thing blowing leaves.”

Photo by Dan Antion

 

“You gotta be kidding.”

“What’s the matter?”

“Riding a blower to the pub?”

“Heavy discount.”

“And high visibility, let alone where to sit.”

“We stand behind the operator.”

“It looks to me like we might be better off walking.”

“That is another thing.”

“What.”

“We have to bag the leaves.”

“Sometimes I wonder about you.”

“It’s good exercise. Here’s your rake and gloves.”

“I can’t wait to see us on the ride home.”

 

 

Friday JohnKu- AKA – TGIF Fri-Yay/Good News

University of Milano-Biocca – credit University press

Today’s Good News comes from the Good News Network. Here it is in its entirety.

Exciting Clinical Trials of New Stem Cell Injection Treatment Shows Promise for Halting Multiple Sclerosis

A collaborative study involving experts in Europe and the US found the treatment of stem cells appears to protect the brains of MS patients from further damage.

In the first-ever clinical trials in humans, the researchers found patients injected with the stem cells exhibited no increase in disability or worsening of symptoms.

The promising study, published in the journal Cell Stem Cell, is hoped to lead to further clinical trials that could provide treatment for progressive MS.

More than two million people live with MS across the globe, and while some treatments currently available can reduce the severity and frequency of relapses, two-thirds of patients still transition into a debilitating secondary progressive phase of the disease within 25 to 30 years of diagnosis.

An autoimmune disorder like Lupus, ALS, and Crohn’s, MS is characterized by the body’s immune system attacking and damaging myelin—the protective sheath of tissue around nerve fibers, disrupting messages sent around the brain and spinal cord.

An immune cell called a microglial can attack the central nervous system in progressive forms of MS, causing chronic inflammation and damage to nerve cells.

Recent scientific advances involving the transplantation of stem cells have raised expectations that therapies could be developed to help ameliorate this damage.

Previous experiments in mice from the Cambridge University unit of the new study team have shown that skin cells reprogrammed to be brain stem cells and transplanted into the nervous system can help to reduce inflammation and may even be able to help repair damage caused by MS.

The research team behind the latest study, incorporating experts from the UK, US, Switzerland, and Italy, completed a world-first early-stage clinical trial in which neural stem cells were injected into the brains of 15 patients with secondary MS recruited from two Italian hospitals.

Along with the Cambridge unit, teams performed the trials at the University of Milano-Bicocca, the Casa Sollievo della Sofferenza and Santa Maria Terni hospitals in Italy, the Ente Ospedaliero Cantonale hospital in Lugano, Switzerland, and the University of Colorado in the United States.

The transplant patients were followed for 12 months. No deaths or serious adverse events related to the treatment were observed throughout the year. Side effects were mild, transient, and reversible.

All patients had a high degree of disability at the start of the clinical trial—for example, they were wheelchair-bound—but during the 12-month observation period, they showed no increase in disability or worsening of symptoms. None of the patients showed symptoms that would indicate a relapse or signs of clinical progression, suggesting substantial stability of the pathology.

A subgroup of patients was also assessed for changes in the volume of brain tissue associated with disease progression, which found that the larger the dose of injected stem cells, the smaller the reduction in this brain volume over time.

The researchers speculate that this may be down to the stem cell transplant dampening inflammation.

Professor Stefano Pluchino, a co-leader of the study from the University of Cambridge, admitted that though the research had limitations, the findings were extremely promising.

“We desperately need to develop new treatments for secondary progressive MS, and I am cautiously very excited about our findings, which are a step towards developing a cell therapy for treating MS,” he said.

“We recognize that our study has limitations: it was only a small study, and there may have been confounding effects from the immunosuppressant drugs, for example, but the fact that our treatment was safe and that its effects lasted over the 12 months of the trial means that we can proceed to the next stage of clinical trials.”

Professor Angelo Vescovi, another co-leader of the study from the University of Milano-Bicocca, added that it has taken nearly three decades to translate the discovery of brain stem cells into this experiment, which he said will “pave the way” to broader studies “soon to come.”

The Good News is that the scientific community is still working on improving life. Today’s JohnKu talks about perspective in a bad news world. I hope you have a wonderful weekend.

Good News by John W. Howell © 2023

The media thinks,

All we want is the horrific . . .

How wrong can they be?