Friday JohnKu – AKA – TGIF – FRI-Yay/Good News

Photo by T-Bone Sandwich, CC license
Today’s story is from the Good News Network. Except for some grammar changes here is the story in its entireity.

Village Saves 45,000 Toads From Roadway Deaths, Cutting Casualties By 60%—All the Way Down to 3% Rate

Dispersed around the UK, hundreds of heroic volunteers soak themselves to the skin on early spring nights in order to save toads, frogs, and newts from being squished under the tires of passing cars.

This network of volunteer societies is literally transforming England by slowly walking across dark asphalt with a high-beam flashlight and a high-visibility jacket, picking up amphibians and dropping them into a bucket for safe transport across the road.

They are reducing the toll of roadkill on local amphibian populations by enormous amounts and ensuring they can keep up their valuable ecosystem services like keeping insect populations in check and filling the spring air with their soft croaking songs.

If you don’t live in a wet or rain-prone area, and you’ve never been on the road during frog/toad mating season, you might think, “How hard is it to just avoid running them over?” But it’s not that simple, for starters, because they can gather in such numbers that swerving to avoid one puts your tires on another, and small frogs and newts look just like leaves and twigs on the dark tarmac through a rain-splattered windshield.

Last year, England’s 203 amphibian rescue groups saved at least 115,000 animals from roads.

The Guardian’s Adrian Sherratt went out one night with Charlcombe Toad Rescue near the ancient city of Bath to photograph and participate in a rainy night’s rescue operations.

This group has brought the number of amphibian deaths from road crossings down to 3% from 60%. When you think that in March, hundreds of mama toads and frogs cross the street with bellies full of eggs, that equates to the survival of thousands of animals.

Bath is renowned for wet areas and hot springs, and frogs and toads need to reach these bodies of water to mate or lay eggs. But being a well-developed area, it involves crossing a lot of roads.

“I find it very emotional, actually,” said Angela, a Charlcombe volunteer. “And it becomes more emotional as you do it. You see a creature that’s so vulnerable just sitting there, and you can see it’s pregnant and bulging with babies. You want them to have a fighting chance of making it to their breeding grounds.”

Charlcombe has been active during the breeding seasons since 2003 and has saved over 40,000 animals from roads. There is a waiting list to join the 50 or so volunteers needed for the operation, which also crowdfunds a £1,500 sum to pay for the main road to be closed during the breeding season.

Froglife is a charity that coordinates the mass data collection that these efforts generate. They also help connect those desiring to volunteer with toad patrols in their area.

On that note, there are dozens and dozens of toad patrol groups that need new members, particularly in Cheshire, Lancashire, and the Isle of Wight.

Today’s JohnKu applauds there volunteers. I hope you have a safe and enjoyable weekend.

Frogs,toads, and newts by John W. Howell © 2012

Frogs, toads, newts, oh my,

Such lowly creatures and yet . . .

There are folks who care.

Friday JohnKu – AKA – TGIF – Fri-Yay/Good News

Nance Fite (baseball hat), Jennifer Lagusker (cowboy hat), and other volunteers posing with the camels – supplied to the media by Jennifer Lagusker

Today’s good news comes from the Good News Network

After Mojave Fires, Camels Help Restore Iconic Joshua Tree Groves in the Cherished California Desert

By Andy Corbley

The Mojave National Preserve is having its iconic Joshua trees restored thanks to a crack team of a dozen volunteers, 3 beasts, and 6 humps.

Following wildfires in 2020 and 2023, the National Parks Service undertook a massive project to breed Joshua trees in nurseries and pack them into the high desert country, and a team of volunteers are using camels to do it.

Camels (two humps), not to be confused with dromedaries (1 hump), would have been present on the North American continent during the last Ice Age thanks to the Bearing Land Bridge, so their presence isn’t a total disturbance.

Indeed, the volunteers working with the camels on behalf of the National Park Service argue they cause less disturbance than mules or horses.

Speaking of the Ice Age, the Mojave Desert’s Joshua tree forests are the most expansive in the country, but they were only able to number in the millions because of the Giant Ground Sloth.

These huge furry mammals fed on the Joshua trees and would have been like double-decker buses for their seeds, carting them around to all corners of the desert. Since the extinction of the Giant Ground Sloth, the plant has had to rely on wind and rodents, with decidedly less success.

– National Parks Service

The germination rate is now extremely low, so the NPS knew the only way to ensure the Joshua tree forests remained as robust as possible was to start a reforestation program for them—setting up a nursery in the Mojave Wilderness Area right on top of the burnt scar from the fires in 2020.

Being that the Mojave is a National Wilderness, there are no roads, no tracks, and no ICE vehicles are permitted inside, so volunteers with the NPS were reduced to hiking hours to the Cima Dome reforestation site with a few seedlings, the cages to protect them, and water to nourish their growth, before having to walk back to the nursery.

Nance Fite, a longtime volunteer at the Mojave National Preserve, realized she had the perfect solution to the arduous task and called up her friend Jennifer Lagusker.

Camels carry Joshua tree seedlings and water in the Mojave – supplied to the media by Jennifer Lagusker

“The job was to pack them and have them carry these things into wherever the park service had us go,” Lagusker told LAist. “When Nance told me about this, I thought, ‘Well, what better way to advocate for the camel than to show the world, hey, they can pack, they really like it, and honestly, they need that kind of a job.’”

Camels are desert specialists, obviously, but their advantages go beyond helping them survive. Their wide and soft feet allow them to pass across the desert wilderness without disturbing the sandy soil and vegetation.

Since 2021, Lagusker and her three camels, Herbie, Sully, and Chico, have been doing most of the restoration work at Cima Dome, a remote area scorched by the wildfires, but after a second round of fires in 2023, the Cima Dome project was considered finished after 3,500 seedlings were successfully planted—carried out into the remote desert on Herbie, Sully, and Chico.

This year,, the caravan is off to another area, where reforestation work on the Joshua trees will continue for a long while.

The good news in this article is that a person thought of a perfect solution to make the project successful. Today’s JohnKu talks about great ideas. I hope you have a wonderful week.

Solution by John W. Howell © 2024

Einstein defined that,

Wanting different results…

From same plan, insane.

Friday JohnKu – AKA – TGIF Fri-Yay/Good News

Family photo courtesy of Sandrine Heute

Today’s good news story comes from the good news network.

Kinder than Chemo Cancer Drug Cured This Young Man of Leukemia–Available in the US

By Andy Corbley

Picture a very unhappy situation: you have leukemia; what are your options? Everyone knows about the side effects of chemo, and most people will have some idea about the Nobel Prize-winning CAR-T cell therapy—but there’s also a third option.

It seems startling to be so overlooked because it’s so straightforward. Blinatumomab cured the young fellow above of his B-cell acute lymphoblastic leukemia.

The BBC reports that 20 medical centers in the UK are already using off-brand stocks of blinatumomab to treat this cancer, and the country has already approved the drug for adult use.

‘Blina,’ as it’s referred to for short, is also an immunotherapy drug; it seeks out and kills cancer cells that typically disguise themselves from the body’s innate immune system. However, unlike chimeric antigen receptor T cells (CAR-T cell), blina is cheaper.

Blina is a kind of targeted therapy drug called a bispecific T-cell engager (BiTE). It’s administered via a pump and plastic bag through a tube inserted into the patient’s arm.

The bag is carried around in a slim backpack, and the supply lasts a few days. CAR-T cell therapy requires a patient’s cells to be taken out and modified to fight off whichever cancer is present—which takes time.

Like CAR-T, the healthy normal cells are not destroyed as in the case of chemotherapy, allowing the patient to continue leading a mostly normal life.

“Chemotherapies are poisons that kill the leukemic cells but also kill and damage normal cells—and that is what causes their side effects,” said chief investigator and consultant pediatric hematologist Professor Ajay Vora to the BBC. “Blinatumomab is a gentler, kinder treatment.”

Gentler on the body—not on the cancer. Arthur, now 11, was one of the first kids to receive the treatment at Great Ormond Street Hospital in London. His family got the word that his blood cancer was cured on New Year’s Eve.

Having started chemo years before, which both left him very weak and failed to kill the cancer, the family called Blina a “little ray of sunshine” and said that they celebrated the new year twice as hard.

On March 29th, 2018, the US Food and Drug Administration granted accelerated approval to blinatumomab after successful trial results, though serious side effects were not uncommon. It’s available for B-cell acute lymphoblastic leukemia treatment.

The good news in this article is Cancer is still under attack, and new discoveries are making survival much more frequent. Today’s JohnKu talks about science. I hope you have a great weekend.

Discoveries by John W. Howell © 2024

The disease still kills,

But science still plods along . . .

Miracle life saves.

Friday JohnKu – AKA – TGIF – Fri-Yay/Good News

Today’s good news story comes from the Epoch Times. This story was sent to me by Noelle Granger. Thanks, Noelle. I have edited it slightly for length.

A picture designed by The Epoch Times using imagery from Nancy Feighan and Molly Shannon/Shutterstock.

‘I Don’t Ask for Anything’: Man, 81, Clears Snow From Neighborhood Sidewalks for Over 20 Years

By Louise Chambers 1/27/2024 Updated: 2/1/2024

An 81-year-old who has been clearing snowy sidewalks in his neighborhood for over 20 years refuses to accept cash donations, insisting he loves the snow and helping his neighbors.

Jimmie Sinatra grew up in Lakewood, Ohio, and bought a house with his wife in the area in 1995. That same year, he invested in his first snowblower. Soon, he upgraded to a Craftsman snowblower that he can walk behind and has been maintaining the prized apparatus ever since.

“I just like snow,” Mr. Sinatra told The Epoch Times. “I love playing in the snow, walking, and taking my dog for a walk in the snow, and I decided to do a couple of neighbors’ sidewalks. Then, when my wife and I talked about getting a bigger snowblower, I decided to go all the way up the block.”

Currently, Mr. Sinatra clears snow from about 34 sidewalks, and if there happens to be a school at the end of each block, he helps there, too, as he hates seeing kids walking in the snow.

Mr. Sinatra clears the streets when the snow reaches 5 or 6 inches deep. Initially, only his immediate neighbors knew that he was helping clear snow for the neighborhood, and those living further down the street had no idea about it. However, over the years, a couple of people have noticed his handiwork and have asked if he could clear their driveways, too.

“I don’t ask for money, I don’t ask for anything, I just do it to help the neighbors,” Mr. Sinatra said. “It’s something for me to do. I enjoy it, that’s all. I enjoy helping people.”

Before retiring in July 1998, Mr. Sinatra worked in the material handling department of the Ford Motor Company in Burke, Ohio, for 33 years. His beloved wife encouraged his snowblowing hobby until she passed away four years ago from Lou Gehrig’s disease.

“That’s the way she was too, helping our neighbors out,” said Mr. Sinatra, who has become a religious man since his wife fell ill. “I changed my ways and just prayed every day and every night,” he said. “I think I used to take everything for granted, but I don’t anymore because it’s all in God’s hands. … I know my wife’s spirit is in the house with me, and that’s what I live for.”

Mr. Sinatra’s routine: 34 sidewalks from the corner of Woodward Avenue and Hillard Road up to Delaware Avenue in Lakewood, Ohio. (Screenshot/Google Maps)

At the age of 81, Mr. Sinatra has his own health problems. In May 2023, he was diagnosed with stage four chronic obstructive pulmonary disease (COPD) and emphysema in both lungs. He has trouble breathing so he wears a scarf to keep warm and carries an inhaler when he leaves the house to clear snow.

And, when he can no longer continue, he hopes that someone will take over and continue to clear the snow on the sidewalks and driveways of people who can’t do it.

“I have a lot of nice neighbors, and they take care of me and watch out for me, check up on me and make sure I’m okay because I’m by myself now,” said Mr. Sinatra, imploring: “If you see somebody that needs help, no matter what it is, give them a helping hand and don’t be afraid to do it. Just help your neighbors and your fellow man out.”

The good news in this story is one man took it upon himself to help his neighbors for the joy of doing so. Today’s JohnKu talks about joy. I hope you have a wonderful weekend.

Helping by John W. Howell

No one has to ask,

It is just the absolute . . .

Joy of helping out.

Friday JohnKu – AKA – TGIF – Fri-Yay/Good News

Today’s good news comes from station KDFW, which serves Dallas and Fort Worth, Texas.

Screengrab of Eban Barns from FoxNews 4

Royse City Boy Scout builds doghouses for Dallas Animal Services

by Lori Brown

An eighth-grade Boy Scout from Royse City is working toward the prestigious Eagle rank by helping save the dogs’ lives in Dallas.

He built and delivered 20 dog houses to Dallas Animal Services this week to be given out to families in need.

Eben Barnes is only 13 years old but already making a big difference

“I really enjoy being around dogs, and I found out that they can be removed from their homes because they don’t have a shelter,” he said. “So I wanted to do a project for that so that dogs wouldn’t be removed.”

Eben reached out to Det. Michael Bono with the Dallas Police Department’s animal cruelty unit to find out how he could help animals in a city that is struggling with shelter overcrowding.

There are almost twice as many dogs in the shelter as there are in the kennels, forcing the shelter to euthanize adoptable pets.

“One of our biggest challenges we have in the animal cruelty unit is individuals that don’t provide a means of shelter,” Bono said. “Whether it’s they just don’t have the means to do so, or they choose not to. But animals in North Texas are at risk based on not having shelter.”

Eben researched how to build a doghouse, but that had its challenges. His prototype broke after the first try. He contacted businesses to collect donations for the supplies he needed.

Eben’s mom, Brooke Barnes, said she was proud of his perseverance.

“He sets a goal and sticks to it,” she said. “So to see him build the prototype, see him get everything organized, and then to see him oversee the work day and the delivery of the doghouses yesterday, it was really exciting.”

And now it’s 20 dogs that will soon have the excitement of their own.

“We’ve seen animals come in because the families just couldn’t provide,” Bono said. “And I think through Evan’s Eagle Scout project, he’s able to help 20 of those families.”

The hope is others will be inspired to follow Eben’s lead.

“I think Eben really nailed this project. I think the doghouses turned out excellent. I think it’s the tip of the iceberg,” Bono said. “I think a lot of other scouts and individuals could do this, and it could greatly impact the greater Dallas and North Texas area.

Eben has now completed all of the requirements to become an Eagle Scout. The next step is his board of review to verify his work.

The good news here is a young man saw a need and did what was necessary to satisfy that need. Today’s JohnKu talks about action. I hope you have a wonderful weekend.

Need by John W. Howell © 2023

There’s a difference,

Between just seeing a need . . .

And action to solve.

 

Friday JohnKu – AKA – TGIF – Fri-Yay/Good News

Today’s good news comes from the Good News Network.

Elton John During His Farewell Yellow Brick Road World Tour, for which he won an Emmy – CC 2.0. slgckgc. Flickr

Elton John Just Achieved EGOT Status with Emmy Win–Only 19 People Have Done It in History

It’s not referring to a tropical disease to say that someone has an EGOT. It means they’ve got a mantlepiece at home where stand an Emmy, a Grammy, an Oscar, and a Tony—the four major pop culture awards in America.

Only 18 entertainers have achieved this quadruple, and now Elton John stands among them as the 19th, having recently won an Emmy for his concert film, Elton John Live: Farewell From Dodger Stadium.

John was not able to attend the ceremony because of needed recovery from knee surgery, “which isn’t surprising if you think of the number of pianos he’s jumped off from in platform heels,” said John’s husband, David Furnish.

John has collected two Oscars: one for The Lion King’s Can You Feel The Love Tonight? and another for Rocketman’s (I’m Gonna) Love Me Again. 

For the ‘T’ in EGOT, he won a Tony for scoring the musical version of the opera Aida. 

For the ‘G’—the Grammy, it’s a case of take your pick, with John having collected quite a few over his decades as a musician.

“I am incredibly humbled to be joining the unbelievably talented group of EGOT winners tonight,” said John in a statement. “The journey to this moment has been filled with passion, dedication, and the unwavering support of my fans all around the world. Tonight is a testament to the power of the arts and the joy that it brings to all our lives. Thank you to everyone who has supported me throughout my career; I am incredibly grateful.”

According to Smithsonian Magazine, the term EGOT was first used on Miami Vice. Its imaginary alumni include Richard Rogers, Hellen Hayes, Rita Moreno, Whoopi Goldberg, Viola Davis, John Legend, Alan Menken, Mell Brooks, Audrey Hepburn, John Gielgud, Marvin Hamlisch, Johnathan Tunic, Mike Nichols, Scott Rudin, Robert Lobez, Andrew Lloyd Weber, Tim Rice, and Jennifer Hudson.

It seems appropriate that the acronym would be finished on Elton’s final show ever on tour in North America, the curtain call of all curtain calls, and a tremendous achievement to mark the end of a long chapter in a tremendous career.

WATCH Tiny Fey and Amy Pohler present the award along with peers…

The good news in this story is that a man who has invested his life and energy into entertainment has been recognized for his achievement and hard work. Today’s JohnKu talks about recognition. I hope you have a wonderful week.

Others by John W. Howell © 2023

When something is great,

And is done by someone else . . .

Do you offer praise?

 

Friday JohnKu – AKA – TGIF Fri-Yay/Good News

Today’s good news story comes from the Good News Network.

Long-Lost ‘Legend’–Leopard Barbel Fish Found Again in Turkey’s Dammed-up Rivers

 

Leopard Barbel (Photo by Metin Yoksu)

 

A team of ichthyologists (zoologists who study fishes) in Türkiye (Turkey) has rediscovered a “legend” in the form of a carp-like, spotted fish called the leopard barbel (Luciobarbus subquincunciatus) in the Turkish section of the Tigris River.

The leopard barbel was once abundant, ranging from Eastern Türkiye, Eastern Syria, Iran, and Iraq in the Tigris-Euphrates river system. Over the last three decades, however, fishing, pollution, habitat destruction, and dam construction have pushed the species to the edge of extinction and was last scientifically documented in 2011.

However, anecdotal evidence from local fishers suggested that the fish may have still been out there, so Associate Professor Cüneyt Kaya and Assistant Professor Münevver Oral at Recep Tayyip Erdogan University enlisted their help to find one.

“There is nothing quite like the feeling of finding that a species that has been pushed to the brink of extinction is still hanging on, despite the odds,” said Kaya upon their success. “It is even more thrilling than discovering a new species because it means that we can give a rare species a second chance.

The team started by looking at the scientific literature about where the species had been previously found. However, those data were collected before nine dams were built in the Turkish portion of the Tigris River.

The dams alter water flow regimes, and cold water accumulating at the reservoirs’ bottom is sometimes released downstream. The release of cold water drives many freshwater fish toward warmer waters, so the team had to adjust its strategy to look further downstream from the dams.

Just days after the second of two expeditions, Kaya and Oral got a video call from local fisherman Mehmet Ülkü. He had caught a 20-inch (50 centimeter), 4.4-pound (2-kilogram) fish with conspicuous black spots and the telltale fleshy filament that dangles from the mouths of this type of freshwater fish.

Ülkü kept the fish alive overnight in a tank with a constant oxygen supply. At the same time, Kaya took a direct flight to the region and then drove nearly six hours to Cizre in the far southeastern reaches of Turkish Kurdistan, where the species was found, while Oral drove more than 11 hours through the night to see the fish and confirm its identity.

By the time they arrived, Ülkü had caught a second leopard barbel safely in his nets, and they were able to help him release the first one as well.

Leopard Barbel after it was released (Photo by Metin Yoksu)

“We dropped everything and would have gone to the ends of the Earth to see this fish, this legend, alive in the wild,” Oral said. “I have never seen a fish as beautiful as this. It was the realization not only of our dream to find this lost species but of the hope that not all is lost—we still have a chance to protect the leopard barbel and all of the other incredible freshwater species it shares its home with.”

After Kaya and Oral took photos and measured the size and shape of the two fish, they were joined by the local Cizre fisheries aquaculture department to release the fish safely, which they described as a joyous event.

“We all have a role to play in protecting our incredible natural heritage, and I am proud to have used my skills to help rediscover the leopard barbel,” Ülkü, the fisherman, said. “Safeguarding this species into the future will require educating other fishers and bringing scientific knowledge and local expertise together.”

Kaya and Oral plan to conduct a series of seminars for fishers and teachers to help build pride in their riverways and wildlife, using the rediscovery as a case study to protect the Tigris River and its rich biodiversity. They are also hoping to better understand how many leopard barbel might still exist and where they are still found across their historic range.

The expedition to confirm the leopard barbel still exists was co-funded by Re:wild, the world leaders rediscovering and protecting lost species. The fish is the second on Re:wild and SHOAL’s Most Wanted Lost Fishes list to be rediscovered. The first, the Batman River loach, was found by the same intrepid team in Southeastern Türkiye in late 2021.

The good news in this situation is that in spite of human negligence, a species fights hard and survives. Today’s JohnKu talks about the ability of animals to survive. I hope you have a beautiful weekend.

Nature by John W. Howell © 2023

In spite of humans,

Species fight hard to survive . . .

Nature can be tough.

Friday JohnKu – AKA – TGIF – Fri-Yay/Good News

White’s seahorse released in Australia – Supplied to ABC News by Dr. David Harasti.

Today’s Good News comes from the Good News Network. Here is the story in its entirety.

100 Tiny Endangered Seahorses Released into Sydney Harbor with High Hopes

By

Australia continues to rehabilitate its populations of White’s seahorse, an “Australian icon” and the only such creature on the nation’s endangered list.

In May, GNN reported that hundreds of White’s seahorses were released into the waters north of Newcastle into specially-made “hotels” as part of the largest release of captive-bred seahorses in history.

Now, as part of another reintroduction, a tide pool north of Sydney Harbor in a place called Clontarf will become the latest release site for these tiny sea creatures.

The seahorses were bred at Sea Life Aquarium in Sydney, and the Aquarium’s curator, Laura Simmons, says the release is just one of several already done and several more planned for 2024.

Also known as the New Holland seahorse, these small animals display a number of very interesting characteristics, including ovoviviparous reproduction, whereby the female creates the eggs and uses an ovipositor to place them in the male’s brood pouch, where they are fertilized and carried until birth.

They also display strong fidelity and seasonal monogamous mating. Their population numbers have been in decline for years.

“We really want to reverse that trend and get them re-established,” Simmons told ABC News AU. “They’re our seahorses, this is an Australian icon.”

Simmons said this release at Clontarf is the sixth release this year, following up on previous successes at Chowder Bay in Sydney Harbour, Botany Bay, and Little Manly Beach, totaling over 400 individual seahorses.

Swimmers at Clontarf may be able to see the seahorses clinging to the habitat net in the tidal pool but are encouraged not to disturb the animals.

The good news is these fragile animals are being given a chance for a comeback. Today’s JohnKu talks about comebacks. I hope you have a wonderful weekend.

Chance by John W. Howell © 2023

A fragile small horse,

Is being given a chance . . .

To make a comeback.

Friday JohnKu- AKA – TGIF Fri-Yay/Good News

University of Milano-Biocca – credit University press

Today’s Good News comes from the Good News Network. Here it is in its entirety.

Exciting Clinical Trials of New Stem Cell Injection Treatment Shows Promise for Halting Multiple Sclerosis

A collaborative study involving experts in Europe and the US found the treatment of stem cells appears to protect the brains of MS patients from further damage.

In the first-ever clinical trials in humans, the researchers found patients injected with the stem cells exhibited no increase in disability or worsening of symptoms.

The promising study, published in the journal Cell Stem Cell, is hoped to lead to further clinical trials that could provide treatment for progressive MS.

More than two million people live with MS across the globe, and while some treatments currently available can reduce the severity and frequency of relapses, two-thirds of patients still transition into a debilitating secondary progressive phase of the disease within 25 to 30 years of diagnosis.

An autoimmune disorder like Lupus, ALS, and Crohn’s, MS is characterized by the body’s immune system attacking and damaging myelin—the protective sheath of tissue around nerve fibers, disrupting messages sent around the brain and spinal cord.

An immune cell called a microglial can attack the central nervous system in progressive forms of MS, causing chronic inflammation and damage to nerve cells.

Recent scientific advances involving the transplantation of stem cells have raised expectations that therapies could be developed to help ameliorate this damage.

Previous experiments in mice from the Cambridge University unit of the new study team have shown that skin cells reprogrammed to be brain stem cells and transplanted into the nervous system can help to reduce inflammation and may even be able to help repair damage caused by MS.

The research team behind the latest study, incorporating experts from the UK, US, Switzerland, and Italy, completed a world-first early-stage clinical trial in which neural stem cells were injected into the brains of 15 patients with secondary MS recruited from two Italian hospitals.

Along with the Cambridge unit, teams performed the trials at the University of Milano-Bicocca, the Casa Sollievo della Sofferenza and Santa Maria Terni hospitals in Italy, the Ente Ospedaliero Cantonale hospital in Lugano, Switzerland, and the University of Colorado in the United States.

The transplant patients were followed for 12 months. No deaths or serious adverse events related to the treatment were observed throughout the year. Side effects were mild, transient, and reversible.

All patients had a high degree of disability at the start of the clinical trial—for example, they were wheelchair-bound—but during the 12-month observation period, they showed no increase in disability or worsening of symptoms. None of the patients showed symptoms that would indicate a relapse or signs of clinical progression, suggesting substantial stability of the pathology.

A subgroup of patients was also assessed for changes in the volume of brain tissue associated with disease progression, which found that the larger the dose of injected stem cells, the smaller the reduction in this brain volume over time.

The researchers speculate that this may be down to the stem cell transplant dampening inflammation.

Professor Stefano Pluchino, a co-leader of the study from the University of Cambridge, admitted that though the research had limitations, the findings were extremely promising.

“We desperately need to develop new treatments for secondary progressive MS, and I am cautiously very excited about our findings, which are a step towards developing a cell therapy for treating MS,” he said.

“We recognize that our study has limitations: it was only a small study, and there may have been confounding effects from the immunosuppressant drugs, for example, but the fact that our treatment was safe and that its effects lasted over the 12 months of the trial means that we can proceed to the next stage of clinical trials.”

Professor Angelo Vescovi, another co-leader of the study from the University of Milano-Bicocca, added that it has taken nearly three decades to translate the discovery of brain stem cells into this experiment, which he said will “pave the way” to broader studies “soon to come.”

The Good News is that the scientific community is still working on improving life. Today’s JohnKu talks about perspective in a bad news world. I hope you have a wonderful weekend.

Good News by John W. Howell © 2023

The media thinks,

All we want is the horrific . . .

How wrong can they be?

 

Friday JohnKu – AKA- TGIF – Fri-Yay/Good News

Photo by Simone Uriartt

Today’s good news story comes from the Good News Network. Here it is in its entirety. Also, for those concerned about Twiggy. The operation was a success, and she is home and resting comfortably. She had a torn meniscus as well as a ligament, so the surgery was a must-do. Twiggy will see you all next Thursday. Thanks for all your messages and well wishes.

Top 30 Most Delightful Things That Happen Unexpectedly–Like Finding Cash in Jeans or Compliments from Strangers

A new poll compiled the top 30 most unexpectedly delightful things to happen, including pulling cash from the pocket of an old pair of jeans, getting a surprise refund, and receiving a compliment from a stranger.

The survey of 2,000 adults found 36 percent love it when someone lets them jump the line in a supermarket and when they find a treasured item that had been lost.

Driving through a run of green lights, catching a whiff of a familiar smell from your childhood, and hearing your favorite song pop up on the radio, also feature in the top 30 list.

(Imagine feeling double the joy if you run into all green lights while your favorite track begins to play!)

Commissioned by Alpen Delight (UK snack brand manufacturer), a spokesperson for the snack brand said: “The nicest things are those which are totally unexpected, and they don’t have to be big things—sometimes little moments lead to big smiles.

Respondents guessed that unexpectedly delightful things happen to them an average of twice per week, and it automatically puts them in a good mood.

But it’s not just being on the receiving end of these unplanned surprises that brings the most joy. 77 percent of those polled find making others happy improves their mood, too—which is why 36 percent try to do this as often as they can.

Such acts include smiling as they walk past another person (52%), just being there to listen to a friend (50%), and telling someone they’re proud of them (38%).

Nearly four in ten have cheered up others by making the effort to cook someone a meal or by letting another driver into their lane while on the road.

And a generous 19% find joy in paying for the meal while out for dinner.

84 percent of those surveyed by market research firm OnePoll, said these moments in life restore a little hope in humanity. And half say they’re more inclined to pay such moments forward if they’ve been on the receiving end themselves.

“It’s good to see how people enjoy delivering, and not just receiving, lovely surprises,” said the Alpen Delight spokesman.

TOP 30 UNEXPECTED MOMENTS OF DELIGHT:

1. Finding money in a coat or jeans pocket
2. Getting a surprise refund
3. A compliment from a stranger
4. Someone letting you go ahead of them in line at a store
5. When the radio plays your favorite song
6. Receiving a bonus at work
7. Constant green lights on the road
8. Hearing your baby’s first word
9. Your partner randomly showing affection
10. When someone actually understands what you’re talking about
11. A familiar smell from your childhood
12. A loved one randomly telling you they’re proud of you
13. Finding a treasured lost item
14. Waking up before your alarm and getting to sleep for longer
15. Getting upgraded – on an airplane or at a hotel
16. Thinking it’s Thursday, but it’s actually Friday
17. When a child starts a conversation with you
18. Receiving a postcard
19. Hitting the exact number when getting gasoline
20. Getting home from work and finding someone else has cooked dinner
21. A work meeting getting canceled last minute because the boss isn’t in
22. Seeing a funny car license plate
23. Getting asked for ID when you’re way over 21
24. When you’re brought breakfast in bed
25. When you and your friend say the same thing at the same moment
26. When your teenager wants to spend quality time with you
27. Your neighbor bringing over a baked good
28. Bumping into an old schoolteacher – and they recognize you
29. Catching the eye of your favorite artist during their performance
30. Witnessing a proposal in public

The good news here is that if we recognize these things that delight others, we can easily do just that. Today’s JohnKu talks about doing unto others. I hope you have a fabulous weekend.

Pay it Forward by John W. Howell © 2023

A list of thirty,

Things that delight other folks . . .

Pick one, go for it.